Probiotic Bacillus coagulans May Help Protect Bone Density in Post-Menopausal Women

Probiotic Bacillus coagulans May Help Protect Bone Density in Post-Menopausal Women

A groundbreaking 2025 study published in Gut Microbes (read the full study here) has revealed that the probiotic Bacillus coagulans may help prevent bone loss in post-menopausal women by restoring gut balance and reducing inflammation — a connection scientists are now calling the “Gut–Immune–Bone Axis.”

The Link Between Gut Health and Bone Strength

Osteoporosis, a condition marked by reduced bone mineral density and an increased risk of fractures, is often considered a hormonal issue. However, new research shows that gut health and inflammation play equally important roles.

In post-menopausal women, estrogen decline disrupts the gut microbiome, leading to:

• Increased gut permeability (“leaky gut”)
• Higher levels of inflammatory bacteria
• Reduced short-chain fatty acid (SCFA) production — compounds vital for bone and immune health

This inflammation triggers overactive bone breakdown cells (osteoclasts) and weakens the immune system’s ability to regulate bone metabolism.

What the Study Found

Researchers supplemented estrogen-deficient (post-menopausal) subjects with Bacillus coagulans, a resilient, spore-forming probiotic known for its immune-modulating and gut-stabilising properties.

The results were striking:

• Improved bone mineral density and strength
• Healthier bone microarchitecture (fewer weak spots and fractures)
• Reduced inflammation through regulation of key immune cells (Bregs, Tregs, and Th17)
• Balanced gut microbiota composition, with an increase in SCFA-producing bacteria

In short, Bacillus coagulans not only helped rebalance the gut, but also reduced inflammation and bone loss, suggesting a new natural approach for managing post-menopausal osteoporosis.

Why Gut Health Plus Fits the Science

The probiotic strain Bacillus coagulans is also found in Gut Health Plus — Propel Health’s advanced synbiotic formula combining:

• Partially Hydrolysed Guar Gum (PHGG) — a gentle prebiotic fibre that feeds beneficial bacteria and promotes SCFA production.
• Bacillus coagulans (Lactospore®) — a clinically backed probiotic that supports digestive balance, immune health, and inflammation control.

Together, they form a synergistic duo that supports not only gut function but also the emerging gut–immune–bone connection — a crucial factor in healthy ageing.

The Takeaway

This new research reinforces that bone health is about more than calcium — it’s about the microbiome. Supporting your gut bacteria with probiotics like Bacillus coagulans and prebiotics like PHGG could become an essential strategy in protecting bone density and reducing inflammation, especially for post-menopausal women.

Learn more about Gut Health Plus — the synbiotic designed to strengthen your gut, support your immune system, and protect long-term bone health naturally.