DHODH Inhibitors: Unlocking New Frontiers in Targeted Therapeutics

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2025-11-17 18:24:33

Understanding DHODH and Its Therapeutic Value Dihydroorotate dehydrogenase (DHODH) is a mitochondrial enzyme critical for de novo pyrimidine synthesis, a pathway essential for rapidly dividing cells such as cancer cells and activated immune cells. By inhibiting DHODH, nucleotide production is disrupted, limiting DNA and RNA synthesis and offering a powerful strategy for therapeutic...

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