A Deep Dive into BAFF/APRIL Pathways and the Advancing Therapeutic...

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2025-11-17 17:28:56

A Deep Dive into BAFF/APRIL Pathways and the Advancing Therapeutic Landscape

Understanding BAFF and APRIL Biology B-cell–activating factor (BAFF) and A Proliferation Inducing Ligand (APRIL) are essential cytokines that guide the survival, activation, and maturation of B cells. When these proteins are overexpressed, they can drive immune-mediated diseases such as systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, and certain B-cell cancers. As...

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