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Cereblon E3 Ligase Modulators: Transforming Targeted Protein Degradation and Redefining the Future of Precision Medicine
Cereblon (CRBN) has emerged as a cornerstone in the advancement of targeted protein degradation. As part of the Cullin 4-RING E3 ubiquitin ligase complex, it is essential in identifying and marking specific proteins for destruction via the proteasome system. This selective degradation regulates vital cellular processes like metabolism, gene expression, and differentiation. Researchers have long...
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