Last Epoch Season 2 Mastery Tier List ranks the 15 masteries based on their overall power, versatility, and performance in endgame content such as Monoliths, bossing, and speed farming Last Epoch Gold.

S-Tier Masteries
1. Void Knight (Sentinel): The top mastery in Season 2, Void Knight excels in survivability, crowd control, and damage. It features powerful builds like Erasing Strike, Rive, and Warpath, making it both beginner-friendly and endgame dominant.
2. Paladin (Sentinel): A consistent favorite, Paladin offers strong defense and damage with popular builds such as Judgment and Hammer Throw. It remains highly competitive and versatile across all content.

A-Tier Masteries
1. Falconer (Rogue): Known for excellent leveling and solid endgame viability, Falconer supports builds like Umbral Blades and Ballista. Its steady performance makes it a reliable choice for many players.
2. Marksman (Rogue): Buoyed by the Heartseeker build hype, Marksman is strong in ranged damage and has good build variety. While it may drop to B-tier if Heartseeker underperforms, it remains a solid pick for archery enthusiasts.
3. Bladedancer (Rogue), Shaman (Primalist), and Druid (Primalist) also fall into A-tier, offering good clear speed and bossing with some limitations compared to S-tier options.

B-Tier Masteries
Includes Forge Guard (Sentinel), Lich (Acolyte), Necromancer (Acolyte), Warlock (Acolyte), Beastmaster (Primalist), Spellblade (Mage), and Runemaster (Mage).These masteries have viable builds but generally lag behind in overall power or versatility. For example, Forge Guard is flavorful but weaker at bossing, while Lich and Warlock have higher death rates in hardcore play.

Summary
Season 2 meta clearly favors Sentinel masteries, especially Void Knight and Paladin, for their balance of offense, defense, and survivability. Rogue masteries like Falconer and Marksman provide strong ranged options, while Primalist and Acolyte subclasses fill out the middle tiers with niche or less consistent performances.

This tier list is dynamic and can shift with patches, but currently, Void Knight and Paladin stand as the best overall masteries for both new and experienced players aiming for endgame success buy Last Epoch Gold.